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Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

Helicases play key roles in genome maintenance, yet it remains elusive how these enzymes change conformations and how transitions between different conformational states regulate nucleic acid reshaping. Here, we developed a computational technique combining structural bioinformatics approaches and a...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Ma, Wen, Whitley, Kevin D, Chemla, Yann R, Luthey-Schulten, Zaida, Schulten, Klaus
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973834/
https://ncbi.nlm.nih.gov/pubmed/29664402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34186
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