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Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase
Helicases play key roles in genome maintenance, yet it remains elusive how these enzymes change conformations and how transitions between different conformational states regulate nucleic acid reshaping. Here, we developed a computational technique combining structural bioinformatics approaches and a...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5973834/ https://ncbi.nlm.nih.gov/pubmed/29664402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34186 |
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