Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion

Real-time quaking-induced conversion (RT-QuIC) is a rapid, specific and highly sensitive prion seeding activity detection assay that uses recombinant prion protein (rPrP(Sen)) to detect subinfectious levels of the abnormal isoforms of the prion protein (PrP(Sc)). Although RT-QuIC has been successful...

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Vydáno v:J Gen Virol
Hlavní autoři: Dassanayake, Rohana P., Orrú, Christina D., Hughson, Andrew G., Caughey, Byron, Graça, Telmo, Zhuang, Dongyue, Madsen-Bouterse, Sally A., Knowles, Donald P., Schneider, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Microbiology Society 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972304/
https://ncbi.nlm.nih.gov/pubmed/26653410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000367
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