The role of BCL11A and HMIP-2 polymorphisms on endogenous and hydroxyurea induced levels of fetal hemoglobin in sickle cell anemia patients from southern Brazil

High levels of fetal hemoglobin (HbF) reduce sickle cell anemia (SCA) morbidity and mortality. HbF levels vary considerably and there is a strong genetic component that influences HbF production. Genetic polymorphisms at three quantitative trait loci (QTL): Xmn1-HBG2, HMIP-2 and BCL11A, have been sh...

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Detalhes bibliográficos
Publicado no:Blood Cells Mol Dis
Main Authors: Friedrisch, João Ricardo, Sheehan, Vivien, Flanagan, Jonathan M., Baldan, Alessandro, Ginter Summarell, Carly C., Bittar, Christina Matzembacher, Friedrisch, Bruno Kras, Wilke, Ianaê Indiara, Ribeiro, Camila Blos, Daudt, Liane Esteves, da Rocha Silla, Lucia Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972079/
https://ncbi.nlm.nih.gov/pubmed/27838552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2016.11.002
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