Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models

Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased efficacy in clinical trials. A better understanding of how tumor heterogen...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Sulheim, Einar, Kim, Jana, van Wamel, Annemieke, Kim, Eugene, Snipstad, Sofie, Vidic, Igor, Grimstad, Ingeborg Hovde, Widerøe, Marius, Torp, Sverre H, Lundgren, Steinar, Waxman, David J, de Lange Davies, Catharina
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972071/
https://ncbi.nlm.nih.gov/pubmed/29684498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.04.026
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