Small molecules that inhibit the late stage of Munc13-4–dependent secretory granule exocytosis in mast cells

Ca(2+)-dependent secretory granule fusion with the plasma membrane is the final step for the exocytic release of inflammatory mediators, neuropeptides, and peptide hormones. Secretory cells use a similar protein machinery at late steps in the regulated secretory pathway, employing protein isoforms f...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Bruinsma, Stephen, James, Declan J., Quintana Serrano, Melanie, Esquibel, Joseph, Woo, Sang Su, Kielar-Grevstad, Elle, Crummy, Ellen, Qurashi, Rehan, Kowalchyk, Judy A., Martin, Thomas F. J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971468/
https://ncbi.nlm.nih.gov/pubmed/29615494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001547
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items