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Identification of a metabolic disposal route for the oncometabolite S-(2-succino)cysteine in Bacillus subtilis
Cellular thiols such as cysteine spontaneously and readily react with the respiratory intermediate fumarate, resulting in the formation of stable S-(2-succino)-adducts. Fumarate-mediated succination of thiols increases in certain tumors and in response to glucotoxicity associated with diabetes. Ther...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5971453/ https://ncbi.nlm.nih.gov/pubmed/29626092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002925 |
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