SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease

BACKGROUND: Oxidative stress is a recognized pathogenic mechanism in chronic obstructive pulmonary disease (COPD). Expression of the NAD(+)-dependent deacetylase Sirtuin 1 (SIRT1), an antiaging molecule with a key role in oxidative stress response, has been described as decreased in the lung of COPD...

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Dettagli Bibliografici
Pubblicato in:Oxid Med Cell Longev
Autori principali: Conti, Valeria, Corbi, Graziamaria, Manzo, Valentina, Malangone, Paola, Vitale, Carolina, Maglio, Angelantonio, Cotugno, Roberta, Capaccio, Damiano, Marino, Luigi, Selleri, Carmine, Stellato, Cristiana, Filippelli, Amelia, Vatrella, Alessandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971245/
https://ncbi.nlm.nih.gov/pubmed/29861836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9391261
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