Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78

Stress-induced cellular defense machinery has a critical role in mediating cancer drug resistance, and targeting stress-related signaling has become a novel strategy to improve chemosensitivity. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid with potent anticancer bioactivitie...

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Библиографические подробности
Опубликовано в: :Cell Death Dis
Главные авторы: Cai, Youli, Zheng, Yifeng, Gu, Jiangyong, Wang, Shengqi, Wang, Neng, Yang, Bowen, Zhang, Fengxue, Wang, Dongmei, Fu, Wenjun, Wang, Zhiyu
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970196/
https://ncbi.nlm.nih.gov/pubmed/29802332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0669-8
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