The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer

Neuropilins (NRP1 and NRP2) are co-receptors for heparin-binding growth factors and class 3 semaphorins. Different isoforms of NRP1 and NRP2 are produced by alternative splicing. We found that in non–small cell lung cancer (NSCLC) cell lines, transforming growth factor–β (TGFβ) signaling preferentia...

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Vydáno v:Sci Signal
Hlavní autoři: Gemmill, Robert M., Nasarre, Patrick, Nair-Menon, Joyce, Cappuzzo, Federico, Landi, Lorenza, D’Incecco, Armida, Uramoto, Hidetaka, Yoshida, Takeshi, Haura, Eric B., Armeson, Kent, Drabkin, Harry A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969810/
https://ncbi.nlm.nih.gov/pubmed/28096505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aag0528
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