Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses

BACKGROUND: Severe hypoglycemia induces brain edema by upregulating aquaporin-4 (AQP4) expression and by degrading tight junctions. Acute severe hypoglycemia induces a proinflammatory environment that may contribute to a disruption in the epithelial barrier by decreasing tight junction protein expre...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Zhao, Fei, Deng, Jiangshan, Xu, Xiaofeng, Cao, Fengya, Lu, Kaili, Li, Dawei, Cheng, Xiaojuan, Wang, Xiuzhe, Zhao, Yuwu
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968550/
https://ncbi.nlm.nih.gov/pubmed/29793504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1203-8
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