Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1

Diabetic nephropathy (DN) is rapidly becoming the leading cause of end-stage renal disease worldwide and a major cause of morbidity and mortality in patients of diabetes. The main pathological change of DN is renal fibrosis. Paeonol (PA), a single phenolic compound extracted from the root bark of Co...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, Lei, Chen, Zhiquan, Gong, Wenyan, Zou, Yezi, Xu, Futian, Chen, Lihao, Huang, Heqing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968333/
https://ncbi.nlm.nih.gov/pubmed/29867511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00512
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