Thymulin, free or bound to PBCA nanoparticles, protects mice against chronic septic inflammation

In the present work, we aimed to study the effects of free and polybutylcyanoacrylate nanoparticle-bound thymulin on immune cell activity in mice with chronic inflammation. NF-κB, MAPK, and PKC-θ signaling pathway activity was assessed, alongside Hsp72, Hsp90-α, and TLR4 expression and levels of apo...

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Veröffentlicht in:PLoS One
Hauptverfasser: Novoselova, Elena G., Lunin, Sergey M., Glushkova, Olga V., Khrenov, Maxim O., Parfenyuk, Svetlana B., Zakharova, Nadezhda M., Fesenko, Evgeny E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967805/
https://ncbi.nlm.nih.gov/pubmed/29795607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197601
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