Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury

Background Ischemia during kidney transplant causes chronic allograft injury and adversely affects outcome, but the underlying mechanisms are incompletely understood. In tumors, oxygen shortage reduces the DNA demethylating activity of the ten-11 translocation (TET) enzymes, yielding hypermethylated...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Am Soc Nephrol
Huvudupphovsmän: Heylen, Line, Thienpont, Bernard, Naesens, Maarten, Busschaert, Pieter, Depreeuw, Jeroen, Smeets, Dominiek, Jochmans, Ina, Monbaliu, Diethard, Pirenne, Jacques, Lerut, Evelyne, Ghesquiere, Bart, Kuypers, Dirk, Lambrechts, Diether, Sprangers, Ben
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Nephrology 2018
Ämnen:
Clinical Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967765/
https://ncbi.nlm.nih.gov/pubmed/29610404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017091027
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk