Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury

Background Ischemia during kidney transplant causes chronic allograft injury and adversely affects outcome, but the underlying mechanisms are incompletely understood. In tumors, oxygen shortage reduces the DNA demethylating activity of the ten-11 translocation (TET) enzymes, yielding hypermethylated...

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Bibliografski detalji
Izdano u:J Am Soc Nephrol
Glavni autori: Heylen, Line, Thienpont, Bernard, Naesens, Maarten, Busschaert, Pieter, Depreeuw, Jeroen, Smeets, Dominiek, Jochmans, Ina, Monbaliu, Diethard, Pirenne, Jacques, Lerut, Evelyne, Ghesquiere, Bart, Kuypers, Dirk, Lambrechts, Diether, Sprangers, Ben
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2018
Teme:
Clinical Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967765/
https://ncbi.nlm.nih.gov/pubmed/29610404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017091027
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