Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury

Background Ischemia during kidney transplant causes chronic allograft injury and adversely affects outcome, but the underlying mechanisms are incompletely understood. In tumors, oxygen shortage reduces the DNA demethylating activity of the ten-11 translocation (TET) enzymes, yielding hypermethylated...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Heylen, Line, Thienpont, Bernard, Naesens, Maarten, Busschaert, Pieter, Depreeuw, Jeroen, Smeets, Dominiek, Jochmans, Ina, Monbaliu, Diethard, Pirenne, Jacques, Lerut, Evelyne, Ghesquiere, Bart, Kuypers, Dirk, Lambrechts, Diether, Sprangers, Ben
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2018
Ábhair:
Clinical Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967765/
https://ncbi.nlm.nih.gov/pubmed/29610404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017091027
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