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Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury
Background Ischemia during kidney transplant causes chronic allograft injury and adversely affects outcome, but the underlying mechanisms are incompletely understood. In tumors, oxygen shortage reduces the DNA demethylating activity of the ten-11 translocation (TET) enzymes, yielding hypermethylated...
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Veröffentlicht in: | J Am Soc Nephrol |
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Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
American Society of Nephrology
2018
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5967765/ https://ncbi.nlm.nih.gov/pubmed/29610404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017091027 |
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