Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury

Background Ischemia during kidney transplant causes chronic allograft injury and adversely affects outcome, but the underlying mechanisms are incompletely understood. In tumors, oxygen shortage reduces the DNA demethylating activity of the ten-11 translocation (TET) enzymes, yielding hypermethylated...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Soc Nephrol
Prif Awduron: Heylen, Line, Thienpont, Bernard, Naesens, Maarten, Busschaert, Pieter, Depreeuw, Jeroen, Smeets, Dominiek, Jochmans, Ina, Monbaliu, Diethard, Pirenne, Jacques, Lerut, Evelyne, Ghesquiere, Bart, Kuypers, Dirk, Lambrechts, Diether, Sprangers, Ben
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Nephrology 2018
Pynciau:
Clinical Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967765/
https://ncbi.nlm.nih.gov/pubmed/29610404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017091027
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