Leptin Signaling Mediates Obesity-associated CSC Enrichment and EMT in Preclinical TNBC Models

Obesity is associated with poor prognosis in triple-negative breast cancer (TNBC). Preclinical models of TNBC were used to test the hypothesis that increased leptin signaling drives obesity-associated TNBC development by promoting cancer stem cell (CSC) enrichment and/or epithelial-to-mesenchymal tr...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Bowers, Laura W., Rossi, Emily L., McDonell, Shannon B., Doerstling, Steven S., Khatib, Subreen A., Lineberger, Claire G., Albright, Jody E., Tang, Xiaohu, deGraffenried, Linda A., Hursting, Stephen D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967653/
https://ncbi.nlm.nih.gov/pubmed/29453319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0508
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