Long-term health and germline transmission in transgenic cattle following transposon-mediated gene transfer

BACKGROUND: Transposon-mediated, non-viral gene delivery is a powerful tool for generating stable cell lines and transgenic animals. However, as multi-copy insertion is the preferred integration pattern, there is the potential for uncontrolled changes in endogenous gene expression and detrimental ef...

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Detalles Bibliográficos
Publicado en:BMC Genomics
Main Authors: Yum, Soo-Young, Lee, Song-Jeon, Park, Sin-Gi, Shin, In-Gang, Hahn, Sang-Eun, Choi, Woo-Jae, Kim, Hee-Soo, Kim, Hyeong-Jong, Bae, Seong-Hun, Lee, Je-Hyeong, Moon, Joo-Yeong, Lee, Woo-Sung, Lee, Ji-Hyun, Lee, Choong-Il, Kim, Seong-Jin, Jang, Goo
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966871/
https://ncbi.nlm.nih.gov/pubmed/29792157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4760-4
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