Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a “U-shaped” relationship

The erythropoietin receptor (EpoR) is widely expressed but its renoprotective action is unexplored. To examine the role of EpoR in vivo in the kidney, we induced acute kidney injury (AKI) by ischemia-reperfusion in mice with different EpoR bioactivities in the kidney. EpoR bioactivity was reduced by...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Shi, Mingjun, Flores, Brianna, Li, Peng, Gillings, Nancy, McMillan, Kathryn L., Ye, Jianfeng, Huang, Lily Jun-Shen, Sidhu, Sachdev S., Zhong, Yong-Ping, Grompe, Maria T., Streeter, Philip R., Moe, Orson W., Hu, Ming Chang
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966758/
https://ncbi.nlm.nih.gov/pubmed/29187371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00306.2017
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