STAT3-Mediated Transcriptional Regulation of Osteopontin in STAT3 Loss-of-Function Related Hyper IgE Syndrome

BACKGROUND: Hyper-IgE syndrome (HIES) caused by loss-of-function (LOF) mutations in STAT3 gene (STAT3 LOF HIES) is associated with dental and facial abnormalities in addition to immunological defects. The role of STAT3 in the pathogenesis of the dental/facial features is, however, poorly elucidated....

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Goel, Shubham, Sahu, Smrity, Minz, Ranjana W., Singh, Surjit, Suri, Deepti, Oh, Young M., Rawat, Amit, Sehgal, Shobha, Saikia, Biman
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966547/
https://ncbi.nlm.nih.gov/pubmed/29868029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01080
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