N-Methyl-D-Aspartate Receptor Co-agonist Availability Affects Behavioral and Neurochemical Responses to Cocaine: Insights into Co-morbid Schizophrenia and Substance Abuse

Both schizophrenia (SZ) and substance abuse (SA) exhibit significant heritability. Moreover, N-methyl-D-aspartate receptors (NMDARs) have been implicated in the pathophysiology of both SZ and SA. We hypothesize that the high prevalence of co-morbid SA in SZ is due to dysfunction of NMDARs caused by...

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Bibliographic Details
Published in:Addict Biol
Main Authors: Puhl, Matthew D., Desai, Rajeev I., Takagi, Shunsuke, Presti, Kendall T., Doyle, Michelle R., Donahue, Rachel J., Landino, Samantha M., Bergman, Jack, Carlezon, William A., Coyle, Joseph T.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966316/
https://ncbi.nlm.nih.gov/pubmed/29168271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12577
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