Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity

Until now, the dopamine (DA) precursor, L-3,4-dihydroxyphenylalanine (L-DOPA), remains the gold standard effective drug therapy for Parkinson’s disease (PD) patients. Nevertheless, long-term chronic L-DOPA administration leads to the drug efficacy loss and severe adverse effects, such as L-DOPA-indu...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Lu, Di-Sheng, Chen, Ce, Zheng, Ya-Xin, Li, Dai-Di, Wang, Guo-Qing, Liu, Jie, Shi, Jingshan, Zhang, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964195/
https://ncbi.nlm.nih.gov/pubmed/29867347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00155
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