High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing

Functional characterization of disease-causing variants at risk loci has been a significant challenge. Here we report a high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) technology to simultaneously screen hundreds to thousands of SNPs for their allele-dependent protein-binding d...

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Udgivet i:Nat Commun
Main Authors: Zhang, Peng, Xia, Ji-Han, Zhu, Jing, Gao, Ping, Tian, Yi-Jun, Du, Meijun, Guo, Yong-Chen, Suleman, Sufyan, Zhang, Qin, Kohli, Manish, Tillmans, Lori S., Thibodeau, Stephen N., French, Amy J., Cerhan, James R., Wang, Li-Dong, Wei, Gong-Hong, Wang, Liang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964124/
https://ncbi.nlm.nih.gov/pubmed/29789573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04451-x
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