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Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning
Chemokine receptors CXCR4 and CCR5 regulate white blood cell trafficking, and are engaged by the HIV-1 envelope glycoprotein gp120 during infection. We combine selection of human CXCR4 and CCR5 libraries comprising nearly all ~7,000 single amino acid substitutions with deep sequencing to define sequ...
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| Udgivet i: | J Immunol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5964024/ https://ncbi.nlm.nih.gov/pubmed/29678950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800343 |
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