Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes

Near-infrared photoimmunotherapy (NIR PIT) employs the photoabsorbing dye IR700 conjugated to antibodies specific for cell surface epidermal growth factor receptor (EGFR). NIR PIT has shown highly selective cytotoxicity in vitro and in vivo. Cell necrosis is thought to be the main mode of cytotoxici...

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Dettagli Bibliografici
Pubblicato in:Free Radic Biol Med
Autori principali: Kishimoto, Shun, Oshima, Nobu, Yamamoto, Kazutoshi, Munasinghe, Jeeva, Ardenkjaer-Larsen, Jan Henrik, Mitchell, James B., Choyke, Peter L., Krishna, Murali C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963721/
https://ncbi.nlm.nih.gov/pubmed/29289705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.12.034
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