Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes

Near-infrared photoimmunotherapy (NIR PIT) employs the photoabsorbing dye IR700 conjugated to antibodies specific for cell surface epidermal growth factor receptor (EGFR). NIR PIT has shown highly selective cytotoxicity in vitro and in vivo. Cell necrosis is thought to be the main mode of cytotoxici...

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Bibliografiske detaljer
Udgivet i:Free Radic Biol Med
Main Authors: Kishimoto, Shun, Oshima, Nobu, Yamamoto, Kazutoshi, Munasinghe, Jeeva, Ardenkjaer-Larsen, Jan Henrik, Mitchell, James B., Choyke, Peter L., Krishna, Murali C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963721/
https://ncbi.nlm.nih.gov/pubmed/29289705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.12.034
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