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TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

Recovery from major depressive disorder is difficult, particularly in patients who are refractory to antidepressant treatments. To examine factors that regulate recovery, we developed a prolonged learned helplessness depression model in mice. After the induction of learned helplessness, mice were se...

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Detalhes bibliográficos
Publicado no:Brain Behav Immun
Main Authors: Cheng, Yuyan, Desse, Sachi, Martinez, Ana, Worthen, Ryan J., Jope, Richard S., Beurel, Eleonore
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963697/
https://ncbi.nlm.nih.gov/pubmed/29452218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2018.02.003
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