The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway

The present study investigates the potential signal pathway of acacetin in cardioprotection against ischemia/reperfusion injury using an in vitro hypoxia/reoxygenation model in primary cultured neonatal rat cardiomyocytes and H9C2 cardiomyoblasts. It was found that acacetin (0.3–3 μM) significantly...

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Publicado en:Front Pharmacol
Autores principales: Wu, Wei-Yin, Li, Yun-Da, Cui, Yu-Kai, Wu, Chan, Hong, Yi-Xiang, Li, Gang, Wu, Yao, Jie, Ling-Jun, Wang, Yan, Li, Gui-Rong
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962741/
https://ncbi.nlm.nih.gov/pubmed/29867499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00497
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