Notch1 Mediates Preconditioning Protection Induced by GPER in Normotensive and Hypertensive Female Rat Hearts

G protein-coupled estrogen receptor (GPER) is an estrogen receptor expressed in the cardiovascular system. G1, a selective GPER ligand, exerts cardiovascular effects through activation of the PI3K-Akt pathway and Notch signaling in normotensive animals. Here, we investigated whether the G1/GPER inte...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Rocca, Carmine, Femminò, Saveria, Aquila, Giorgio, Granieri, Maria C., De Francesco, Ernestina M., Pasqua, Teresa, Rigiracciolo, Damiano C., Fortini, Francesca, Cerra, Maria C., Maggiolini, Marcello, Pagliaro, Pasquale, Rizzo, Paola, Angelone, Tommaso, Penna, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962667/
https://ncbi.nlm.nih.gov/pubmed/29867564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00521
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