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Molecular Size Modulates Pharmacokinetics, Biodistribution, and Renal Deposition of the Drug Delivery Biopolymer Elastin-like Polypeptide

Elastin-like polypeptides (ELP) are engineered proteins that consist of repetitions of a five amino acid motif, and their composition is easily modified to adjust their physical properties and attach therapeutics. Because of the repetitive nature of the ELP sequence, polymer size is particularly ame...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kuna, Marija, Mahdi, Fakhri, Chade, Alejandro R., Bidwell, Gene L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962569/
https://ncbi.nlm.nih.gov/pubmed/29784932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24897-9
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