Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair

Genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) predominantly induces non-homologous end joining (NHEJ), which generates random insertions or deletions, whereas homology-directed repair (HDR), which generates precise recombin...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Kato-Inui, Tomoko, Takahashi, Gou, Hsu, Szuyin, Miyaoka, Yuichiro
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961419/
https://ncbi.nlm.nih.gov/pubmed/29672770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky264
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