A natural non-Watson–Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations

Six pathogenic mutations have been reported in human mitochondrial tRNA(Thr) (hmtRNA(Thr)); however, the pathogenic molecular mechanism remains unclear. Previously, we established an activity assay system for human mitochondrial threonyl-tRNA synthetase (hmThrRS). In the present study, we surveyed t...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Wang, Yong, Zeng, Qi-Yu, Zheng, Wen-Qiang, Ji, Quan-Quan, Zhou, Xiao-Long, Wang, En-Duo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961198/
https://ncbi.nlm.nih.gov/pubmed/29648639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky243
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