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A natural non-Watson–Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations
Six pathogenic mutations have been reported in human mitochondrial tRNA(Thr) (hmtRNA(Thr)); however, the pathogenic molecular mechanism remains unclear. Previously, we established an activity assay system for human mitochondrial threonyl-tRNA synthetase (hmThrRS). In the present study, we surveyed t...
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| Foilsithe in: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Oxford University Press
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5961198/ https://ncbi.nlm.nih.gov/pubmed/29648639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky243 |
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