MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

The MIR137 locus is a replicated genetic risk factor for schizophrenia. The risk-associated allele is reported to increase miR-137 expression and miR-137 overexpression alters synaptic transmission in mouse hippocampus. We investigated the cellular mechanisms underlying these observed effects in mou...

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Publicat a:Hum Mol Genet
Autors principals: He, Enqi, Lozano, Miguel A Gonzalez, Stringer, Sven, Watanabe, Kyoko, Sakamoto, Kensuke, den Oudsten, Frank, Koopmans, Frank, Giamberardino, Stephanie N, Hammerschlag, Anke, Cornelisse, L Niels, Li, Ka Wan, van Weering, Jan, Posthuma, Danielle, Smit, August B, Sullivan, Patrick F, Verhage, Matthijs
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961183/
https://ncbi.nlm.nih.gov/pubmed/29635364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy089
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