Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation—the NCT Neuro Master Match (N(2)M(2)) pilot study

BACKGROUND: O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma patients. Glioblastoma without hypermethylated MGMT promoter is largely resistant to treatment with temozolomide. These patients are in particular need of new treatment a...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Pfaff, Elke, Kessler, Tobias, Balasubramanian, Gnana Prakash, Berberich, Anne, Schrimpf, Daniel, Wick, Antje, Debus, Jürgen, Unterberg, Andreas, Bendszus, Martin, Herold-Mende, Christel, Capper, David, Schenkel, Irini, Eisenmenger, Andreas, Dettmer, Susan, Brors, Benedikt, Platten, Michael, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Wick, Wolfgang, Sahm, Felix
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Clinical Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961072/
https://ncbi.nlm.nih.gov/pubmed/29165638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox216
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