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The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS

Complex II (SdhABCD) is a membrane-bound component of mitochondrial and bacterial electron transport chains, as well as of the TCA cycle. In this capacity, it catalyzes the reversible oxidation of succinate. SdhABCD contains the SDHA protein harboring a covalently bound FAD redox center and the iron...

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Pubblicato in:J Biol Chem
Autori principali: Maklashina, Elena, Rajagukguk, Sany, Iverson, T. M., Cecchini, Gary
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961047/
https://ncbi.nlm.nih.gov/pubmed/29610278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001977
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