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A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α
The integrated stress response (ISR) is regulated by kinases that phosphorylate the α subunit of translation initiation factor 2 and phosphatases that dephosphorylate it. Genetic and biochemical observations indicate that the eIF2α(P)-directed holophosphatase, a therapeutic target in diseases of pro...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5961032/ https://ncbi.nlm.nih.gov/pubmed/29618508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002325 |
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