Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice

IFN regulatory factor 3 (IRF3) is a transcription regulator of cellular responses in many cell types that is known to be essential for innate immunity. To confirm IRF3’s broad role in immunity and to more fully discern its role in various cellular subsets, we engineered Irf3-floxed mice to allow for...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Yanai, Hideyuki, Chiba, Shiho, Hangai, Sho, Kometani, Kohei, Inoue, Asuka, Kimura, Yoshitaka, Abe, Takaya, Kiyonari, Hiroshi, Nishio, Junko, Taguchi-Atarashi, Naoko, Mizushima, Yu, Negishi, Hideo, Grosschedl, Rudolf, Taniguchi, Tadatsugu
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960330/
https://ncbi.nlm.nih.gov/pubmed/29712834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803936115
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