Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice

IFN regulatory factor 3 (IRF3) is a transcription regulator of cellular responses in many cell types that is known to be essential for innate immunity. To confirm IRF3’s broad role in immunity and to more fully discern its role in various cellular subsets, we engineered Irf3-floxed mice to allow for...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yanai, Hideyuki, Chiba, Shiho, Hangai, Sho, Kometani, Kohei, Inoue, Asuka, Kimura, Yoshitaka, Abe, Takaya, Kiyonari, Hiroshi, Nishio, Junko, Taguchi-Atarashi, Naoko, Mizushima, Yu, Negishi, Hideo, Grosschedl, Rudolf, Taniguchi, Tadatsugu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960330/
https://ncbi.nlm.nih.gov/pubmed/29712834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803936115
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