Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1

BRCA1 is essential for repair of DNA double-strand breaks by homologous recombination, and hence for survival. Complete loss of its function is lethal during early embryonic development. Patients who are compound heterozygous for BRCA1 truncating mutations and missense alleles that retain some DNA r...

全面介紹

Na minha lista:
書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Seo, Aaron, Steinberg-Shemer, Orna, Unal, Sule, Casadei, Silvia, Walsh, Tom, Gumruk, Fatma, Shalev, Stavit, Shimamura, Akiko, Akarsu, Nurten Ayse, Tamary, Hannah, King, Mary-Claire
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960323/
https://ncbi.nlm.nih.gov/pubmed/29712865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801796115
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍