Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson’s disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA) neurotransmission. Previous studies of...

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Bibliografische gegevens
Gepubliceerd in:PeerJ
Hoofdauteurs: Tarasova, Tatiana V., Lytkina, Olga A., Goloborshcheva, Valeria V., Skuratovskaya, Larisa N., Antohin, Alexandr I., Ovchinnikov, Ruslan K., Kukharsky, Michail S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: PeerJ Inc. 2018
Onderwerpen:
Developmental Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960258/
https://ncbi.nlm.nih.gov/pubmed/29785351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.4779
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