Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons

BACKGROUND: 3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only a few KstDs have thus far been characterized biochemically and applied for the production of steroidal pharmaceutical intermediates. Three KstDs, KstD1, Kst...

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Publicado en:Microb Cell Fact
Autores principales: Zhang, Ruijie, Liu, Xiangcen, Wang, Yushi, Han, Yuchang, Sun, Junsong, Shi, Jiping, Zhang, Baoguo
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960168/
https://ncbi.nlm.nih.gov/pubmed/29776364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-018-0916-9
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