The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway

BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-like peptide-1 (GLP-1) cleavage. Interestingly, gliptins can also improve strok...

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Detalhes bibliográficos
Publicado no:Cardiovasc Diabetol
Main Authors: Chiazza, Fausto, Tammen, Harald, Pintana, Hiranya, Lietzau, Grazyna, Collino, Massimo, Nyström, Thomas, Klein, Thomas, Darsalia, Vladimer, Patrone, Cesare
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960142/
https://ncbi.nlm.nih.gov/pubmed/29776406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-018-0702-3
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