Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome

BACKGROUND: Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine (SN), a bioactive alkaloid with anti-inflammatory effect, exerts neuroprotectiv...

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Bibliografske podrobnosti
izdano v:J Neuroinflammation
Main Authors: Gao, Bo, Wu, Yu, Yang, Yuan-Jian, Li, Wei-Zu, Dong, Kun, Zhou, Jun, Yin, Yan-Yan, Huang, Da-Ke, Wu, Wen-Ning
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960124/
https://ncbi.nlm.nih.gov/pubmed/29776417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1199-0
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