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Improved effectiveness of stereotactic radiosurgery in large brain metastases by individualized isotoxic dose prescription: an in silico study

INTRODUCTION: In large brain metastases (BM) with a diameter of more than 2 cm there is an increased risk of radionecrosis (RN) with standard stereotactic radiosurgery (SRS) dose prescription, while the normal tissue constraint is exceeded. The tumor control probability (TCP) with a single dose of 1...

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Bibliographic Details
Published in:Strahlenther Onkol
Main Authors: Zindler, Jaap D., Schiffelers, Jacqueline, Lambin, Philippe, Hoffmann, Aswin L.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959984/
https://ncbi.nlm.nih.gov/pubmed/29349605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00066-018-1262-x
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