Copper-binding small molecule induces oxidative stress and cell cycle arrest in glioblastoma-patient-derived cells

Transition metals are essential, but deregulation of their metabolism causes toxicity. Here, we report that the compound NSC319726 binds copper to induce oxidative stress and arrest glioblastoma-patient-derived cells at picomolar concentrations. Pharmacogenomic analysis suggested that NSC319726 and...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Shimada, Kenichi, Reznik, Eduard, Stokes, Michael E., Krishnamoorthy, Lakshmi, Bos, Pieter H., Song, Yuyu, Quartararo, Christine E., Pagano, Nen C., Carpizo, Darren R., deCarvalho, Ana C., Lo, Donald C., Stockwell, Brent R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959763/
https://ncbi.nlm.nih.gov/pubmed/29576531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.02.010
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