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EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response
Mutations in eIF2B genes cause vanishing white matter disease (VWMD), a fatal leukodystrophy that can manifest following physical trauma or illness, conditions that activate the integrated stress response (ISR). EIF2B is the guanine exchange factor for eIF2, facilitating ternary complex formation an...
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| Pubblicato in: | RNA |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5959252/ https://ncbi.nlm.nih.gov/pubmed/29632131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.066563.118 |
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