RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes

The identification of telomerase-negative HAATI (heterochromatin amplification-mediated and telomerase-independent) cells, in which telomeres are superseded by nontelomeric heterochromatin tracts, challenged the idea that canonical telomeres are essential for chromosome linearity and raised crucial...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Begnis, Martina, Apte, Manasi S., Masuda, Hirohisa, Jain, Devanshi, Wheeler, David Lee, Cooper, Julia Promisel
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959237/
https://ncbi.nlm.nih.gov/pubmed/29654060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311712.118
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