RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes

The identification of telomerase-negative HAATI (heterochromatin amplification-mediated and telomerase-independent) cells, in which telomeres are superseded by nontelomeric heterochromatin tracts, challenged the idea that canonical telomeres are essential for chromosome linearity and raised crucial...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Dev
Prif Awduron: Begnis, Martina, Apte, Manasi S., Masuda, Hirohisa, Jain, Devanshi, Wheeler, David Lee, Cooper, Julia Promisel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2018
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959237/
https://ncbi.nlm.nih.gov/pubmed/29654060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311712.118
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