Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify t...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Hommel, Benjamin, Mukaremera, Liliane, Cordero, Radames J. B., Coelho, Carolina, Desjardins, Christopher A., Sturny-Leclère, Aude, Janbon, Guilhem, Perfect, John R., Fraser, James A., Casadevall, Arturo, Cuomo, Christina A., Dromer, Françoise, Nielsen, Kirsten, Alanio, Alexandre
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959062/
https://ncbi.nlm.nih.gov/pubmed/29775480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006982
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