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High-throughput, image-based screening of pooled genetic variant libraries

Image-based, high-throughput screening of genetic perturbations will advance both biology and biotechnology. We report a high-throughput screening method that allows diverse genotypes and corresponding phenotypes to be imaged in numerous individual cells. We achieve genotyping by introducing barcode...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Emanuel, George, Moffitt, Jeffrey R., Zhuang, Xiaowei
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958624/
https://ncbi.nlm.nih.gov/pubmed/29083401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4495
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