CD4(+) T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema

T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4(+) T cells are necessary for lymphedema pathogenesis by utilizing adoptive transfer techniques in CD4 knockout mice that...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: García Nores, Gabriela D., Ly, Catherine L., Cuzzone, Daniel A., Kataru, Raghu P., Hespe, Geoffrey E., Torrisi, Jeremy S., Huang, Jung Ju, Gardenier, Jason C., Savetsky, Ira L., Nitti, Matthew D., Yu, Jessie Z., Rehal, Sonia, Mehrara, Babak J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958132/
https://ncbi.nlm.nih.gov/pubmed/29773802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04418-y
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